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BMCBI
2010
121views more  BMCBI 2010»
13 years 4 months ago
A grammar-based distance metric enables fast and accurate clustering of large sets of 16S sequences
Background: We propose a sequence clustering algorithm and compare the partition quality and execution time of the proposed algorithm with those of a popular existing algorithm. T...
David J. Russell, Samuel F. Way, Andrew K. Benson,...
BMCBI
2007
127views more  BMCBI 2007»
13 years 7 months ago
CORRIE: enzyme sequence annotation with confidence estimates
Using a previously developed automated method for enzyme annotation, we report the reannotation of the ENZYME database and the analysis of local error rates per class. In control ...
Benjamin Audit, Emmanuel D. Levy, Walter R. Gilks,...
BMCBI
2002
108views more  BMCBI 2002»
13 years 7 months ago
A memory-efficient dynamic programming algorithm for optimal alignment of a sequence to an RNA secondary structure
Background: Covariance models (CMs) are probabilistic models of RNA secondary structure, analogous to profile hidden Markov models of linear sequence. The dynamic programming algo...
Sean R. Eddy
NAR
2006
75views more  NAR 2006»
13 years 7 months ago
DrugBank: a comprehensive resource for in silico drug discovery and exploration
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical)data withcomprehensive drug target (i.e.protein) information. The database ...
David S. Wishart, Craig Knox, Anchi Guo, Savita Sh...
NAR
2010
116views more  NAR 2010»
13 years 2 months ago
The European Bioinformatics Institute's data resources
As the amount of biological data grows, so does the need for biologists to store and access this information in central repositories in a free and unambiguous manner. The European...
Catherine Brooksbank, Graham Cameron, Janet M. Tho...