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CCE
2008
13 years 7 months ago
Optimal delivery of chemotherapeutic agents in cancer
In this paper, derivation of the optimal chemotherapy schedule is formulated and solved as a dynamic optimization problem. For this purpose two models representing the tumour grow...
Pinky Dua, Vivek Dua, Efstratios N. Pistikopoulos
NAR
2008
141views more  NAR 2008»
13 years 7 months ago
MethyCancer: the database of human DNA methylation and cancer
Cancer is ranked as one of the top killers in all human diseases and continues to have a devastating effect on the population around the globe. Current research efforts are aiming...
Ximiao He, Suhua Chang, Jiajie Zhang, Qian Zhao, H...
CIBCB
2007
IEEE
14 years 1 months ago
Spectral Decomposition of Signaling Networks
—Many dynamical processes can be represented as directed attributed graphs or Petri nets where relationships between various entities are explicitly expressed. Signaling networks...
Bahram Parvin, Nirmalya Ghosh, Laura Heiser, Merri...
BMCBI
2007
94views more  BMCBI 2007»
13 years 7 months ago
A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays
Background: Affymetrix SNP arrays can interrogate thousands of SNPs at the same time. This allows us to look at the genomic content of cancer cells and to investigate the underlyi...
Philippe Lamy, Claus L. Andersen, Lars Dyrskjot, N...
BMCBI
2008
82views more  BMCBI 2008»
13 years 7 months ago
Standardized high-throughput evaluation of cell-based compound screens
Background: High-throughput screening of pharmaceutical compound activity in tissue culture experiments requires time-consuming repeated analysis of the large amounts of data gene...
Peter Frommolt, Roman K. Thomas