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BMCBI
2002
75views more  BMCBI 2002»
13 years 10 months ago
Quantifying robustness of biochemical network models
Background: Robustness of mathematical models of biochemical networks is important for validation purposes and can be used as a means of selecting between different competing mode...
Lan Ma, Pablo A. Iglesias
BMCBI
2002
128views more  BMCBI 2002»
13 years 10 months ago
Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in euka
Background: Gene regulation in eukaryotes is mainly effected through transcription factors binding to rather short recognition motifs generally located upstream of the coding regi...
Michele Caselle, Ferdinando Di Cunto, Paolo Prover...
BMCBI
2002
95views more  BMCBI 2002»
13 years 10 months ago
The functional importance of disease-associated mutation
Background: For many years, scientists believed that point mutations in genes are the genetic switches for somatic and inherited diseases such as cystic fibrosis, phenylketonuria ...
Sean D. Mooney, Teri E. Klein
BMCBI
2002
81views more  BMCBI 2002»
13 years 10 months ago
Species-specific protein sequence and fold optimizations
Background: An organism's ability to adapt to its particular environmental niche is of fundamental importance to its survival and proliferation. In the largest study of its k...
Michel Dumontier, Katerina Michalickova, Christoph...
BMCBI
2002
99views more  BMCBI 2002»
13 years 10 months ago
FunSpec: a web-based cluster interpreter for yeast
Background: For effective exposition of biological information, especially with regard to analysis of large-scale data types, researchers need immediate access to multiple categor...
Mark D. Robinson, Jörg Grigull, Naveed Mohamm...