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JCB
2007
94views more  JCB 2007»
13 years 8 months ago
A Quantile Method for Sizing Optical Maps
Optical mapping is an integrated system for the analysis of single DNA molecules. It constructs restriction maps (noted as “optical map”) from individual DNA molecules present...
Haifeng Li, Anton Valouev, David C. Schwartz, Mich...
BMCBI
2004
81views more  BMCBI 2004»
13 years 8 months ago
Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis
Background: Mutations in rpoB, the gene encoding the subunit of DNA-dependent RNA polymerase, are associated with rifampin resistance in Mycobacterium tuberculosis. Several studi...
Michael P. Cummings, Mark R. Segal
BMCBI
2002
101views more  BMCBI 2002»
13 years 8 months ago
Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases
Background: Total sequence decomposition, using the web-based MASIA tool, identifies areas of conservation in aligned protein sequences. By structurally annotating these motifs, t...
Catherine H. Schein, Numan Özgün, Tadahi...
BMCBI
2007
147views more  BMCBI 2007»
13 years 8 months ago
Statistical significance of quantitative PCR
Background: PCR has the potential to detect and precisely quantify specific DNA sequences, but it is not yet often used as a fully quantitative method. A number of data collection...
Yann Karlen, Alan McNair, Sébastien Persegu...
BMCBI
2006
152views more  BMCBI 2006»
13 years 8 months ago
Amplification of the Gene Ontology annotation of Affymetrix probe sets
Background: The annotations of Affymetrix DNA microarray probe sets with Gene Ontology terms are carefully selected for correctness. This results in very accurate but incomplete a...
Enrique M. Muro, Carolina Perez-Iratxeta, Miguel A...