BMCBI
2011
13 years 2 months ago
2011
Background: Tumor cells are considered to have an aberrant cell state, and some evidence indicates different development states appearing in the tumorigenesis. Embryonic developme...
BMCBI
2011
13 years 2 months ago
2011
Background: The analysis of protein structures provides fundamental insight into most biochemical functions and consequently into the cause and possible treatment of diseases. As ...
BMCBI
2011
13 years 2 months ago
2011
Background: Cluster analysis is a crucial tool in several biological and medical studies dealing with microarray data. Such studies pose challenging statistical problems due to di...
BMCBI
2011
13 years 2 months ago
2011
Background: Computational analysis of metagenomes requires the taxonomical assignment of the genome contigs assembled from DNA reads of environmental samples. Because of the diver...
BMCBI
2011
13 years 2 months ago
2011
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
BMCBI
2011
13 years 2 months ago
2011
Background: In many environmental genomics applications a homologous region of DNA from a diverse sample is first amplified by PCR and then sequenced. The next generation sequenci...
BMCBI
2011
13 years 2 months ago
2011
BMCBI
2011
13 years 2 months ago
2011
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
BMCBI
2011
13 years 2 months ago
2011
Background: The amount of data on protein-protein interactions (PPIs) available in public databases and in the literature has rapidly expanded in recent years. PPI data can provid...
BMCBI
2011
13 years 2 months ago
2011
Background: The Gene Ontology (GO) Consortium organizes genes into hierarchical categories based on biological process, molecular function and subcellular localization. Tools such...