BMCBI
2011
13 years 2 months ago
2011
Background: The interest in non-coding RNAs (ncRNAs) constantly rose during the past few years because of the wide spectrum of biological processes in which they are involved. Thi...
BMCBI
2011
13 years 2 months ago
2011
Background: DNA microarrays have become a nearly ubiquitous tool for the study of human disease, and nowhere is this more true than in cancer. With hundreds of studies and thousan...
BMCBI
2011
13 years 2 months ago
2011
Background: Large databases of genetic data are often biased in their representation. Thus, selection of genetic data with desired properties, such as evolutionary representation ...
BMCBI
2011
13 years 2 months ago
2011
BMCBI
2011
13 years 2 months ago
2011
Background: In rule-based modeling, graphs are used to represent molecules: a colored vertex represents a component of a molecule, a vertex attribute represents the internal state...
BMCBI
2011
13 years 2 months ago
2011
Background: Typical analysis of microarray data ignores the correlation between gene expression values. In this paper we present a model for microarray data which specifically all...
BMCBI
2011
13 years 2 months ago
2011
Background: Atomic Solvation Parameters (ASP) model has been proven to be a very successful method of calculating the binding free energy of protein complexes. This suggests that ...
BMCBI
2011
13 years 2 months ago
2011
Background: Genomic position (GP) files currently used in next-generation sequencing (NGS) studies are always difficult to manipulate due to their huge size and the lack of approp...
BMCBI
2011
13 years 2 months ago
2011
Background: High-throughput screening (HTS) is a key part of the drug discovery process during which thousands of chemical compounds are screened and their activity levels measure...
BMCBI
2011
13 years 2 months ago
2011
Background: During meiosis, homologous chromosomes exchange segments via the formation of crossovers. This phenomenon is highly regulated; in particular, crossovers are distribute...