Peptide compositions constructed out of whole sets of protein sequences can be used as species signatures for phylogenetic analysis. To account for point mutations, an amino acid ...
The availability of entire genome sequences, coupled with genome-wide studies of gene expression, offers promise for discovering new pathways along with their regulatory programs....
HIV-1-associated dementia (HAD) is the most devastating disease happened in the central nervous system of AIDS patients. Neuronal damage, the early indicator of HAD, under differe...
DNA microarray experiments generate a substantial amount of information about global gene expression. Gene expression profiles can be represented as points in multi-dimensional sp...
Lu-Yong Wang, Ammaiappan Balasubramanian, Amit Cha...
Our paper describes the first provably-efficient algorithm for determining protein structures de novo, solely from experimental data. We show how the global nature of a certain ...
Lincong Wang, Ramgopal R. Mettu, Bruce Randall Don...
Understanding the relationship between protein structure and its sequence is one of the most important tasks of current bioinformatics research. In this work, recurring protein se...
Wei Zhong, Gulsah Altun, Robert W. Harrison, Phang...
Studying the genetic control of molecular, anatomical and/or morphological phenotypes in model organisms is a powerful tool in the functional analysis of a gene. The goal of our r...
Alexander Vaughan, Rahul Singh, Ilmi Yoon, Megumi ...
Annotation of protein function often arises in the context of partially complete genomes but is not adequately addressed. We present an annotation method by extracting ortholog cl...
Akshay Vashist, Casimir A. Kulikowski, Ilya B. Muc...
Microarray experiments are characterized by a massive amount of data, usually in the form of an image. Based on the nature of microarray images, we consider the microarray in term...