BMCBI
2005
13 years 11 months ago
2005
Background: Gene expression programs depend on recognition of cis elements in promoter region of target genes by transcription factors (TFs), but how TFs regulate gene expression ...
BMCBI
2005
13 years 11 months ago
2005
: One of the most evident achievements of bioinformatics is the development of methods that transfer biological knowledge from characterised proteins to uncharacterised sequences. ...
BMCBI
2005
13 years 11 months ago
2005
Background: The use of mass spectrometry as a proteomics tool is poised to revolutionize early disease diagnosis and biomarker identification. Unfortunately, before standard super...
BMCBI
2005
13 years 11 months ago
2005
BMCBI
2005
13 years 11 months ago
2005
Background: The large gap between the number of protein sequences in databases and the number of functionally characterized proteins calls for the development of a fast computatio...
BMCBI
2005
13 years 11 months ago
2005
Background: The availability of interaction databases provides an opportunity for researchers to utilize immense amounts of data exclusively in silico. Recently there has been an ...
BMCBI
2005
13 years 11 months ago
2005
Background: Microarray experiments, as well as other genomic analyses, often result in large gene sets containing up to several hundred genes. The biological significance of such ...
BMCBI
2005
13 years 11 months ago
2005
Background: It is common for the results of a microarray study to be analyzed in the context of biologically-motivated groups of genes such as pathways or Gene Ontology categories...
BMCBI
2005
13 years 11 months ago
2005
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
BMCBI
2005
13 years 11 months ago
2005
Background: Users of microarray technology typically strive to use universally acceptable data analysis strategies to determine significant expression changes in their experiments...