BMCBI
2008
13 years 11 months ago
2008
Background: Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson corre...
BMCBI
2008
13 years 11 months ago
2008
Background: The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints ...
BMCBI
2008
13 years 11 months ago
2008
Background: High-throughput microarrays are widely used to study gene expression across tissues and developmental stages. Analysis of gene expression data is challenging in these ...
BMCBI
2008
13 years 11 months ago
2008
Background: Depending on their specific structures, noncoding RNAs (ncRNAs) play important roles in many biological processes. Interest in developing new topological indices based...
BMCBI
2008
13 years 11 months ago
2008
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
BMCBI
2008
13 years 11 months ago
2008
Background: An increasing number of scientific research projects require access to large-scale computational resources. This is particularly true in the biological field, whether ...
BMCBI
2008
13 years 11 months ago
2008
Background: There is an urgent need for new prognostic markers of breast cancer metastases to ensure that newly diagnosed patients receive appropriate therapy. Recent studies have...
BMCBI
2008
13 years 11 months ago
2008
Background: Cis-regulatory modules (CRMs) are distinct, genomic regions surrounding the target gene that can independently activate the promoter to drive transcription. The activa...
BMCBI
2008
13 years 11 months ago
2008
Background: GenBank flatfile (GBF) format is one of the most popular sequence file formats because of its detailed sequence features and ease of readability. To use the data in th...
BMCBI
2008
13 years 11 months ago
2008
Background: The expansion of automatic imaging technologies has created a need to be able to efficiently compare and review large sets of image data. To enable comparisons of imag...