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BMCBI
2008
79views more  BMCBI 2008»
13 years 11 months ago
Pathological rate matrices: from primates to pathogens
Harold W. Schranz, Von Bing Yap, Simon Easteal, Ro...
BMCBI
2008
104views more  BMCBI 2008»
13 years 11 months ago
Missing value imputation improves clustering and interpretation of gene expression microarray data
Background: Missing values frequently pose problems in gene expression microarray experiments as they can hinder downstream analysis of the datasets. While several missing value i...
Johannes Tuikkala, Laura Elo, Olli Nevalainen, Ter...
BMCBI
2008
131views more  BMCBI 2008»
13 years 11 months ago
Major copy proportion analysis of tumor samples using SNP arrays
Background: Single nucleotide polymorphisms (SNPs) are the most common genetic variations in the human genome and are useful as genomic markers. Oligonucleotide SNP microarrays ha...
Cheng Li, Rameen Beroukhim, Barbara A. Weir, Wendy...
BMCBI
2008
182views more  BMCBI 2008»
13 years 11 months ago
MiMiR - an integrated platform for microarray data sharing, mining and analysis
Background: Despite considerable efforts within the microarray community for standardising data format, content and description, microarray technologies present major challenges i...
Chris Tomlinson, Manjula Thimma, Stelios Alexandra...
BMCBI
2008
110views more  BMCBI 2008»
13 years 11 months ago
Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
Wei Dai, Jens M. Teodoridis, Janet Graham, Constan...
BMCBI
2008
58views more  BMCBI 2008»
13 years 11 months ago
Discrimination of outer membrane proteins with improved performance
Background: Outer membrane proteins (OMPs) perform diverse functional roles in Gramnegative bacteria. Identification of outer membrane proteins is an important task. Results: This...
Changhui Yan, Jing Hu, Yingfeng Wang
BMCBI
2008
109views more  BMCBI 2008»
13 years 11 months ago
ConStruct: Improved construction of RNA consensus structures
Background: Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect s...
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
BMCBI
2008
155views more  BMCBI 2008»
13 years 11 months ago
AMMOS: Automated Molecular Mechanics Optimization tool for in silico Screening
Background: Virtual or in silico ligand screening combined with other computational methods is one of the most promising methods to search for new lead compounds, thereby greatly ...
Tania Pencheva, David Lagorce, Ilza Pajeva, Bruno ...
BMCBI
2008
193views more  BMCBI 2008»
13 years 11 months ago
Missing value imputation for microarray gene expression data using histone acetylation information
Background: It is an important pre-processing step to accurately estimate missing values in microarray data, because complete datasets are required in numerous expression profile ...
Qian Xiang, Xianhua Dai, Yangyang Deng, Caisheng H...
BMCBI
2008
113views more  BMCBI 2008»
13 years 11 months ago
SNPFile - A software library and file format for large scale association mapping and population genetics studies
Background: High-throughput genotyping technology has enabled cost effective typing of thousands of individuals in hundred of thousands of markers for use in genome wide studies. ...
Jesper Nielsen, Thomas Mailund