BMCBI
2008
13 years 11 months ago
2008
Background: Expression profiles obtained from multiple perturbation experiments are increasingly used to reconstruct transcriptional regulatory networks, from well studied, simple...
BMCBI
2008
13 years 11 months ago
2008
Background: The regulation of gene expression is complex and occurs at many levels, including transcriptional and post-transcriptional, in metazoans. Transcriptional regulation is...
BMCBI
2008
13 years 11 months ago
2008
Background: The expressed sequence tag (EST) methodology is an attractive option for the generation of sequence data for species for which no completely sequenced genome is availa...
BMCBI
2008
13 years 11 months ago
2008
Background: Utilization of alternative initiation sites for protein translation directed by non-AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative in...
BMCBI
2008
13 years 11 months ago
2008
Background: Mass spectrometry for biological data analysis is an active field of research, providing an efficient way of high-throughput proteome screening. A popular variant of m...
BMCBI
2008
13 years 11 months ago
2008
Background: Discriminating membrane proteins based on their functions is an important task in genome annotation. In this work, we have analyzed the characteristic features of amin...
BMCBI
2008
13 years 11 months ago
2008
Background: While text-mining and distributed annotation systems both aim at capturing knowledge and presenting it in a standardized form, there have been few attempts to investig...
BMCBI
2008
13 years 11 months ago
2008
Background: Mixture models of mutagenetic trees are evolutionary models that capture several pathways of ordered accumulation of genetic events observed in different subsets of pa...
BMCBI
2008
13 years 11 months ago
2008
Background: Contact order is a topological descriptor that has been shown to be correlated with several interesting protein properties such as protein folding rates and protein tr...
BMCBI
2008
13 years 11 months ago
2008
Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite divers...