BMCBI
2010
13 years 11 months ago
2010
Background: Semantic similarity scores for protein pairs are widely applied in functional genomic researches for finding functional clusters of proteins, predicting protein functi...
BMCBI
2010
13 years 11 months ago
2010
Background: A key challenge in systems biology is the reconstruction of an organism's metabolic network from its genome sequence. One strategy for addressing this problem is ...
BMCBI
2010
2010
Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data
13 years 11 months ago
Background: Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and th...
BMCBI
2010
13 years 11 months ago
2010
Background: Large genomes contain families of highly similar genes that cannot be individually identified by microarray probes. This limitation is due to thermodynamic restriction...
BMCBI
2010
13 years 11 months ago
2010
Background: Genetic interaction profiles are highly informative and helpful for understanding the functional linkages between genes, and therefore have been extensively exploited ...
BMCBI
2010
13 years 11 months ago
2010
Background: Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric manner. H...
BMCBI
2010
13 years 11 months ago
2010
Background: With the growing amount of biomedical data available in public databases it has become increasingly important to annotate data in a consistent way in order to allow ea...
BMCBI
2010
13 years 11 months ago
2010
Background: Bacterial infections represent a global health challenge. The identification of novel antibacterial targets for both therapy and vaccination is needed on a constant ba...
BMCBI
2010
13 years 11 months ago
2010
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
BMCBI
2010
13 years 11 months ago
2010
Background: The impressive increase of novel RNA structures, during the past few years, demands automated methods for structure comparison. While many algorithms handle only small...