BMCBI
2010
13 years 11 months ago
2010
Background: The increasing availability and diversity of omics data in the post-genomic era offers new perspectives in most areas of biomedical research. Graph-based biological ne...
BMCBI
2010
13 years 11 months ago
2010
Background: We analysed 48 non-redundant antibiotic target proteins from all bacteria, 22 antibiotic target proteins from E. coli only and 4243 non-drug targets from E. coli to id...
BMCBI
2010
13 years 11 months ago
2010
Background: Comparative analysis of gene expression profiling of multiple biological categories, such as different species of organisms or different kinds of tissue, promises to e...
BMCBI
2010
13 years 11 months ago
2010
Background: Machine learning techniques have shown to improve bacterial species classification based on fatty acid methyl ester (FAME) data. Nonetheless, FAME analysis has a limit...
BMCBI
2010
13 years 11 months ago
2010
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
BMCBI
2010
13 years 11 months ago
2010
Background: Algorithms and software for CNV detection have been developed, but they detect the CNV regions sample-by-sample with individual-specific breakpoints, while common CNV ...
BMCBI
2010
13 years 11 months ago
2010
Background: Image analysis is an essential component in many biological experiments that study gene expression, cell cycle progression, and protein localization. A protocol for tr...
BMCBI
2010
13 years 11 months ago
2010
Background: Recent studies have shown that copy number variations (CNVs) are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk...
BMCBI
2010
13 years 11 months ago
2010
Background: Normalization in real-time qRT-PCR is necessary to compensate for experimental variation. A popular normalization strategy employs reference gene(s), which may introdu...
BMCBI
2010
13 years 11 months ago
2010
Background: In recent years, the demand for computational power in computational biology has increased due to rapidly growing data sets from microarray and other high-throughput t...