BMCBI
2011
13 years 6 months ago
2011
Background: Atomic Solvation Parameters (ASP) model has been proven to be a very successful method of calculating the binding free energy of protein complexes. This suggests that ...
BMCBI
2011
13 years 6 months ago
2011
Background: Genomic position (GP) files currently used in next-generation sequencing (NGS) studies are always difficult to manipulate due to their huge size and the lack of approp...
BMCBI
2011
13 years 6 months ago
2011
Background: High-throughput screening (HTS) is a key part of the drug discovery process during which thousands of chemical compounds are screened and their activity levels measure...
BMCBI
2011
13 years 6 months ago
2011
Background: During meiosis, homologous chromosomes exchange segments via the formation of crossovers. This phenomenon is highly regulated; in particular, crossovers are distribute...
BMCBI
2011
13 years 6 months ago
2011
Background: With the advent of cost-effective genotyping technologies, genome-wide association studies allow researchers to examine hundreds of thousands of single nucleotide poly...
BMCBI
2011
13 years 6 months ago
2011
Background: In order to interpret the results obtained from a microarray experiment, researchers often shift focus from analysis of individual differentially expressed genes to an...
BMCBI
2011
13 years 6 months ago
2011
Background: Visualization of orthogonal (disjoint) or overlapping datasets is a common task in bioinformatics. Few tools exist to automate the generation of extensively-customizab...
BMCBI
2011
13 years 6 months ago
2011
Background: The increasing availability of molecular sequence data means that the accuracy of future phylogenetic studies is likely to by limited by systematic bias and taxon choi...
BMCBI
2011
13 years 6 months ago
2011
BMCBI
2011
13 years 6 months ago
2011
Background: Caenorhabditis elegans gene-based phenotype information dates back to the 1970’s, beginning with Sydney Brenner and the characterization of behavioral and morphologi...