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JCB
2006
71views more  JCB 2006»
13 years 7 months ago
Multiple Testing Methods For ChIP - Chip High Density Oligonucleotide Array Data
Sündüz Keles, Mark J. van der Laan, Sand...
JCB
2006
185views more  JCB 2006»
13 years 7 months ago
Identification of Amino Acid Latent Periodicity within 94 Protein Families
Here, we have applied information decomposition, cyclic profile alignment, and noise decomposition techniques to search for latent repeats within protein families of various funct...
Vera P. Turutina, Andrew A. Laskin, Nikolay A. Kud...
JCB
2006
107views more  JCB 2006»
13 years 7 months ago
Maximum Likelihood Molecular Clock Comb: Analytic Solutions
Maximum likelihood (ML) is increasingly used as an optimality criterion for selecting evolutionary trees, but finding the global optimum is a hard computational task. Because no g...
Benny Chor, Amit Khetan, Sagi Snir
JCB
2006
66views more  JCB 2006»
13 years 7 months ago
Pairwise Alignment of Protein Interaction Networks
With an ever-increasing amount of available data on protein
Mehmet Koyutürk, Yohan Kim, Umut Topkara, Sha...
JCB
2006
76views more  JCB 2006»
13 years 7 months ago
An Optimal Algorithm for Perfect Phylogeny Haplotyping
Ravi Vijaya Satya, Amar Mukherjee
JCB
2006
67views more  JCB 2006»
13 years 7 months ago
The Identifiability of Tree Topology for Phylogenetic Models, Including Covarion and Mixture Models
For a model of molecular evolution to be useful for phylogenetic inference, the topology of evolutionary trees must be identifiable. That is, from a joint distribution the model p...
Elizabeth S. Allman, John A. Rhodes
JCB
2006
144views more  JCB 2006»
13 years 7 months ago
Modeling Virus Self-Assembly Pathways: Avoiding Dynamics Using Geometric Constraint Decomposition
We develop a model for elucidating the assembly pathways by which an icosahedral viral shell forms from 60 identical constituent protein monomers. This poorly understood process a...
Meera Sitharam, Mavis Agbandje-Mckenna
JCB
2006
83views more  JCB 2006»
13 years 7 months ago
A Discrete-Event Approach to Transcription Control with Dynamic Event-Controllability
This paper presents a discrete-event approach to synthesis of transcription control for a class of (computational) gene networks. Given a set of genes and protein-gene and/or prote...
Peter C. Y. Chen
JCB
2006
114views more  JCB 2006»
13 years 7 months ago
A General Modeling Strategy for Gene Regulatory Networks with Stochastic Dynamics
A stochastic genetic toggle switch model that consists of two identical, mutually repressive genes is built using the Gillespie algorithm with time delays as an example of a simpl...
Andre Ribeiro, Rui Zhu, Stuart A. Kauffman
JCB
2006
185views more  JCB 2006»
13 years 7 months ago
Bayesian Sequential Inference for Stochastic Kinetic Biochemical Network Models
As postgenomic biology becomes more predictive, the ability to infer rate parameters of genetic and biochemical networks will become increasingly important. In this paper, we expl...
Andrew Golightly, Darren J. Wilkinson