BMCBI
2005
14 years 10 days ago
2005
Background: Molecular Biology accumulated substantial amounts of data concerning functions of genes and proteins. Information relating to functional descriptions is generally extr...
BMCBI
2005
14 years 10 days ago
2005
Background: The application of high throughput approaches to the identification of protein interactions has offered for the first time a glimpse of the global interactome of some ...
BMCBI
2005
14 years 10 days ago
2005
Background: The identification of local similarities between two protein structures can provide clues of a common function. Many different methods exist for searching for similar ...
BMCBI
2005
14 years 10 days ago
2005
Background: Text mining has spurred huge interest in the domain of biology. The goal of the BioCreAtIvE exercise was to evaluate the performance of current text mining systems. We...
BMCBI
2005
14 years 10 days ago
2005
Background: Identification of gene and protein names in biomedical text is a challenging task as the corresponding nomenclature has evolved over time. This has led to multiple syn...
BMCBI
2005
14 years 10 days ago
2005
Background: Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independenc...
BMCBI
2005
14 years 10 days ago
2005
Background: Predicting the subcellular localization of proteins is important for determining the function of proteins. Previous works focused on predicting protein localization in...
BMCBI
2005
14 years 10 days ago
2005
Background: Cells react to changing intra- and extracellular signals by dynamically modulating complex biochemical networks. Cellular responses to extracellular signals lead to ch...
BMCBI
2005
14 years 10 days ago
2005
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
BMCBI
2005
14 years 10 days ago
2005
Background: Currently, the PDB contains approximately 29,000 protein structures comprising over 70,000 experimentally determined three-dimensional structures of over 5,000 differe...