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132
Voted
BMCBI
2007
144views more  BMCBI 2007»
15 years 25 days ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...
128
Voted
BMCBI
2007
148views more  BMCBI 2007»
15 years 25 days ago
Blast sampling for structural and functional analyses
Background: The post-genomic era is characterised by a torrent of biological information flooding the public databases. As a direct consequence, similarity searches starting with ...
Anne Friedrich, Raymond Ripp, Nicolas Garnier, Emm...
COMBINATORICS
2006
92views more  COMBINATORICS 2006»
15 years 26 days ago
Meta-Fibonacci Sequences, Binary Trees and Extremal Compact Codes
We consider a family of meta-Fibonacci sequences which arise in studying the number of leaves at the largest level in certain infinite sequences of binary trees, restricted compos...
Brad Jackson, Frank Ruskey
103
Voted
COMBINATORICS
2006
98views more  COMBINATORICS 2006»
15 years 26 days ago
Shift Equivalence of P-finite Sequences
We present an algorithm which decides the shift equivalence problem for Pfinite sequences. A sequence is called P-finite if it satisfies a homogeneous linear recurrence equation w...
Manuel Kauers
123
Voted
CANDC
2006
ACM
15 years 26 days ago
Dealing with repetitions in sequencing by hybridization
DNA sequencing by hybridization (SBH) induces errors in the biochemical experiment. Some of them are random and disappear when the experiment is repeated. Others are systematic, i...
Jacek Blazewicz, Fred Glover, Marta Kasprzak, Wojc...
99
Voted
BMCBI
2006
75views more  BMCBI 2006»
15 years 26 days ago
A machine learning strategy to identify candidate binding sites in human protein-coding sequence
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...
Thomas Down, Bernard Leong, Tim J. P. Hubbard
BMCBI
2006
87views more  BMCBI 2006»
15 years 26 days ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
114
Voted
BMCBI
2006
92views more  BMCBI 2006»
15 years 26 days ago
A jumping profile Hidden Markov Model and applications to recombination sites in HIV and HCV genomes
Background: Jumping alignments have recently been proposed as a strategy to search a given multiple sequence alignment A against a database. Instead of comparing a database sequen...
Anne-Kathrin Schultz, Ming Zhang, Thomas Leitner, ...
127
Voted
BMCBI
2006
115views more  BMCBI 2006»
15 years 26 days ago
The accuracy of several multiple sequence alignment programs for proteins
Background: There have been many algorithms and software programs implemented for the inference of multiple sequence alignments of protein and DNA sequences. The "true" ...
Paulo A. S. Nuin, Zhouzhi Wang, Elisabeth R. M. Ti...
108
Voted
BMCBI
2006
101views more  BMCBI 2006»
15 years 26 days ago
How repetitive are genomes?
Background: Genome sequences vary strongly in their repetitiveness and the causes for this are still debated. Here we propose a novel measure of genome repetitiveness, the index o...
Bernhard Haubold, Thomas Wiehe