NAR
2011
13 years 2 months ago
2011
During the development of methods for cancer diagnosis and treatment, a vast amount of information is generated. Novel cancer target proteins have been identified and many compoun...
NAR
2011
13 years 2 months ago
2011
MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (sRNAs) that regulate gene expression by targeting messenger RNAs. However, assigning miRNAs to their regu...
BMCBI
2011
13 years 2 months ago
2011
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
NAR
2008
13 years 9 months ago
2008
MicroRNAs (miRNAs) constitute an important class of regulators that are involved in various cellular and disease processes. However, the functional significance of each miRNA is m...
NAR
2007
13 years 10 months ago
2007
Transcriptional factors (TFs) and many of their target genes are involved in gene regulation at the level of transcription. To decipher gene regulatory networks (GRNs) we require ...
BMCBI
2007
13 years 11 months ago
2007
Background: The central role of transcription factors (TFs) in higher eukaryotes has led to much interest in deciphering transcriptional regulatory interactions. Even in the best ...
BMCBI
2007
13 years 11 months ago
2007
Background: The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlapping functions in pivotal cellular processes such as DNA synthesis a...
BIOINFORMATICS
2006
13 years 11 months ago
2006
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
BMCBI
2008
13 years 11 months ago
2008
Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules (20
BMCBI
2010
13 years 11 months ago
2010
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...