Safe autonomous flight is essential for widespread acceptance of aircraft that must fly close to the ground. We have developed a methodology of collision avoidance that can be used in three dimensions in much the same way as autonomous ground vehicles that navigate over unexplored terrain. Safe navigation is accomplished by a combination of online environmental sensing, path planning and collision avoidance. Here we outline our methodology and report results with an autonomous helicopter that operates at low elevations in uncharted environments some of which are densely populated with obstacles such as buildings, trees and wires. We have recently completed over 700 successful runs in which the helicopter traveled between coarsely specified waypoints separated by hundreds of meters, at speeds up to 10 meters/sec at elevations of 5-11 meters above ground level. The helicopter safely avoids large objects like buildings and trees but also wires as thin as 6 mm. We believe this represents ...