With deep-sub-micron (DSM) technology, statistical timing analysis becomes increasingly crucial to characterize signal transmission over global interconnect wires. In this paper, a novel statistical timing analysis approach has been developed to analyze the behavior of two important pipelined architectures for multiple clock-cycle global interconnect, namely, the flip-flop inserted global wire and the latch inserted global wire. We present analytical formula that is based on parameters obtained using Monte Carlo simulation. These results enable a global interconnect designer to explore design trade-offs between clock frequency and probability of bit-error during data transmission. Categories and Subject Descriptors B.8 [Hardware]: Performance and Reliability General Terms Algorithms, Performance, Design, Reliability Keywords Statistical Timing Analysis, Interconnect Pipelining