CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowled

During the development of methods for cancer diagnosis and treatment, a vast amount of information is generated. Novel cancer target proteins have been identified and many compounds that activate or inhibit cancer-relevant target genes have been developed. This knowledge is based on an immense number of experimentally validated compound–target interactions in the literature, and excerpts from literature text mining are spread over numerous data sources. Our own analysis shows that the overlap between important existing repositories such as Comparative Toxicogenomics Database (CTD), Therapeutic Target Database (TTD), Pharmacogenomics Knowledge Base (PharmGKB) and DrugBank as well as between our own literature mining for cancer-annotated entries is surprisingly small. In order to provide an easy overview of interaction data, it is essential to integrate this information into a single, comprehensive data repository. Here, we present CancerResource, a database that integrates cancer-rel...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Jessica Ahmed, Thomas Meinel, Mathias Dunkel, Manuela S. Murgueitio, Robert Adams, Corinna Blasse, Andreas Eckert, Saskia Preissner, Robert Preissner
• Keywords: NAR 2011, Target Database, Target Genes, Target Proteins