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» Smoothing Gene Expression Using Biological Networks
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BMCBI
2011
13 years 13 days ago
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in Bre
Background: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biologi...
Hiroko K. Solvang, Ole Christian Lingjærde, ...
APBC
2004
164views Bioinformatics» more  APBC 2004»
13 years 10 months ago
Cluster Ensemble and Its Applications in Gene Expression Analysis
Huge amount of gene expression data have been generated as a result of the human genomic project. Clustering has been used extensively in mining these gene expression data to find...
Xiaohua Hu, Illhoi Yoo
CSB
2005
IEEE
130views Bioinformatics» more  CSB 2005»
14 years 2 months ago
iSimBioSys: An "In Silico" Discrete Event Simulation Framework for Modeling Biological Systems
The genome projects have provided comprehensive information about the basic building blocks of life. The next challenge is to understand how biological functions emerge from compl...
Samik Ghosh, Preetam Ghosh, Kalyan Basu, Sajal K. ...
RECOMB
2004
Springer
14 years 9 months ago
Probabilistic discovery of overlapping cellular processes and their regulation
In this paper, we explore modeling overlapping biological processes. We discuss a probabilistic model of overlapping biological processes, gene membership in those processes, and ...
Alexis Battle, Eran Segal, Daphne Koller
BMCBI
2006
86views more  BMCBI 2006»
13 years 8 months ago
Identification of QTLs controlling gene expression networks defined a priori
Background: Gene expression microarrays allow the quantification of transcript accumulation for many or all genes in a genome. This technology has been utilized for a range of inv...
Daniel J. Kliebenstein, Marilyn A. L. West, Hans v...