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BMCBI
2006
147views more  BMCBI 2006»
13 years 11 months ago
A hidden Markov model approach for determining expression from genomic tiling micro arrays
Background: Genomic tiling micro arrays have great potential for identifying previously undiscovered coding as well as non-coding transcription. To-date, however, analyses of thes...
Kasper Munch, Paul P. Gardner, Peter Arctander, An...
BMCBI
2006
187views more  BMCBI 2006»
13 years 11 months ago
Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false
Background: Nonlinear regression, like linear regression, assumes that the scatter of data around the ideal curve follows a Gaussian or normal distribution. This assumption leads ...
Harvey J. Motulsky, Ronald E. Brown
BMCBI
2006
109views more  BMCBI 2006»
13 years 11 months ago
GPNN: Power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease
Background: The identification and characterization of genes that influence the risk of common, complex multifactorial disease primarily through interactions with other genes and ...
Alison A. Motsinger, Stephen L. Lee, George Mellic...
BMCBI
2006
144views more  BMCBI 2006»
13 years 11 months ago
More robust detection of motifs in coexpressed genes by using phylogenetic information
Background: Several motif detection algorithms have been developed to discover overrepresented motifs in sets of coexpressed genes. However, in a noisy gene list, the number of ge...
Pieter Monsieurs, Gert Thijs, Abeer A. Fadda, Sigr...
BMCBI
2006
123views more  BMCBI 2006»
13 years 11 months ago
How to decide? Different methods of calculating gene expression from short oligonucleotide array data will give different result
Background: Short oligonucleotide arrays for transcript profiling have been available for several years. Generally, raw data from these arrays are analysed with the aid of the Mic...
Frank F. Millenaar, John Okyere, Sean T. May, Mart...
BMCBI
2006
146views more  BMCBI 2006»
13 years 11 months ago
Optimized Particle Swarm Optimization (OPSO) and its application to artificial neural network training
Background: Particle Swarm Optimization (PSO) is an established method for parameter optimization. It represents a population-based adaptive optimization technique that is influen...
Michael Meissner, Michael Schmuker, Gisbert Schnei...
BMCBI
2006
169views more  BMCBI 2006»
13 years 11 months ago
Comparative analysis of haplotype association mapping algorithms
Background: Finding the genetic causes of quantitative traits is a complex and difficult task. Classical methods for mapping quantitative trail loci (QTL) in miceuse an F2 cross b...
Phillip McClurg, Mathew T. Pletcher, Tim Wiltshire...
BMCBI
2006
74views more  BMCBI 2006»
13 years 11 months ago
Effects of filtering by Present call on analysis of microarray experiments
Background: Affymetrix GeneChips
Jeanette N. McClintick, Howard J. Edenberg
BMCBI
2006
134views more  BMCBI 2006»
13 years 11 months ago
Application of machine learning in SNP discovery
Background: Single nucleotide polymorphisms (SNP) constitute more than 90% of the genetic variation, and hence can account for most trait differences among individuals in a given ...
Lakshmi K. Matukumalli, John J. Grefenstette, Davi...
BMCBI
2006
92views more  BMCBI 2006»
13 years 11 months ago
Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays
Background: Genetic markers hold great promise for refining our ability to establish precise prognostic prediction for diseases. The development of comprehensive gene expression m...
Shigeyuki Matsui