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BMCBI
2008
67views more  BMCBI 2008»
13 years 11 months ago
Multi-label literature classification based on the Gene Ontology graph
Bo Jin, Brian Muller, Chengxiang Zhai, Xinghua Lu
BMCBI
2008
82views more  BMCBI 2008»
13 years 11 months ago
Standardized high-throughput evaluation of cell-based compound screens
Background: High-throughput screening of pharmaceutical compound activity in tissue culture experiments requires time-consuming repeated analysis of the large amounts of data gene...
Peter Frommolt, Roman K. Thomas
BMCBI
2008
160views more  BMCBI 2008»
13 years 11 months ago
A method for analyzing censored survival phenotype with gene expression data
Background: Survival time is an important clinical trait for many disease studies. Previous works have shown certain relationship between patients' gene expression profiles a...
Tongtong Wu, Wei Sun, Shinsheng Yuan, Chun-Houh Ch...
BMCBI
2008
202views more  BMCBI 2008»
13 years 11 months ago
Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data
Background: Integrating data from multiple global assays and curated databases is essential to understand the spatiotemporal interactions within cells. Different experiments measu...
Yuji Zhang, Jianhua Xuan, Benildo de los Reyes, Ro...
BMCBI
2008
244views more  BMCBI 2008»
13 years 11 months ago
RNAalifold: improved consensus structure prediction for RNA alignments
Background: The prediction of a consensus structure for a set of related RNAs is an important first step for subsequent analyses. RNAalifold, which computes the minimum energy str...
Stephan H. F. Bernhart, Ivo L. Hofacker, Sebastian...
BMCBI
2008
153views more  BMCBI 2008»
13 years 11 months ago
Estimating the size of the solution space of metabolic networks
Background: Cellular metabolism is one of the most investigated system of biological interactions. While the topological nature of individual reactions and pathways in the network...
Alfredo Braunstein, Roberto Mulet, Andrea Pagnani
BMCBI
2008
153views more  BMCBI 2008»
13 years 11 months ago
2DB: a Proteomics database for storage, analysis, presentation, and retrieval of information from mass spectrometric experiments
Background: The amount of information stemming from proteomics experiments involving (multi dimensional) separation techniques, mass spectrometric analysis, and computational anal...
Jens Allmer, Sebastian Kuhlgert, Michael Hippler
BMCBI
2008
178views more  BMCBI 2008»
13 years 11 months ago
Identification of coherent patterns in gene expression data using an efficient biclustering algorithm and parallel coordinate vi
Background: The DNA microarray technology allows the measurement of expression levels of thousands of genes under tens/hundreds of different conditions. In microarray data, genes ...
Kin-On Cheng, Ngai-Fong Law, Wan-Chi Siu, Alan Wee...
BMCBI
2008
121views more  BMCBI 2008»
13 years 11 months ago
Microarray data mining using landmark gene-guided clustering
Background: Clustering is a popular data exploration technique widely used in microarray data analysis. Most conventional clustering algorithms, however, generate only one set of ...
Pankaj Chopra, Jaewoo Kang, Jiong Yang, HyungJun C...
BMCBI
2008
118views more  BMCBI 2008»
13 years 11 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden