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BMCBI
2008
125views more  BMCBI 2008»
13 years 11 months ago
SNPLims: a data management system for genome wide association studies
Background: Recent progresses in genotyping technologies allow the generation high-density genetic maps using hundreds of thousands of genetic markers for each DNA sample. The ava...
Alessandro Orro, Guia Guffanti, Erika Salvi, Fabio...
BMCBI
2008
122views more  BMCBI 2008»
13 years 11 months ago
Reconstructing networks of pathways via significance analysis of their intersections
Background: Significance analysis at single gene level may suffer from the limited number of samples and experimental noise that can severely limit the power of the chosen statist...
Mirko Francesconi, Daniel Remondini, Nicola Nerett...
BMCBI
2008
179views more  BMCBI 2008»
13 years 11 months ago
Improving the power for detecting overlapping genes from multiple DNA microarray-derived gene lists
Background: In DNA microarray gene expression profiling studies, a fundamental task is to extract statistically significant genes that meet certain research hypothesis. Currently,...
Xutao Deng, Jun Xu, Charles Wang
BMCBI
2008
97views more  BMCBI 2008»
13 years 11 months ago
Large-scale directional relationship extraction and resolution
Background: Relationships between entities such as genes, chemicals, metabolites, phenotypes and diseases in MEDLINE are often directional. That is, one may affect the other in a ...
Cory B. Giles, Jonathan D. Wren
BMCBI
2008
106views more  BMCBI 2008»
13 years 11 months ago
Integrating biological data - the Distributed Annotation System
Background: The Distributed Annotation System (DAS) is a widely adopted protocol for dynamically integrating a wide range of biological data from geographically diverse sources. D...
Andrew M. Jenkinson, Mario Albrecht, Ewan Birney, ...
BMCBI
2008
62views more  BMCBI 2008»
13 years 11 months ago
Scientific Laboratory Information Management System: Tissue Bank
ent> <title> <p>UT-ORNL-KBRIN Bioinformatics Summit 2008</p> </title> <editor>Eric C Rouchka and Julia Krushkal</editor> <note>Meeting ...
Chanchai McDonald, Anand Kulkarni, Teeradache Vian...
BMCBI
2008
144views more  BMCBI 2008»
13 years 11 months ago
Rule-based knowledge aggregation for large-scale protein sequence analysis of influenza A viruses
Background: The explosive growth of biological data provides opportunities for new statistical and comparative analyses of large information sets, such as alignments comprising te...
Olivo Miotto, Tin Wee Tan, Vladimir Brusic
BMCBI
2008
256views more  BMCBI 2008»
13 years 11 months ago
TrypanoCyc - a metabolic pathway database for Trypanosoma brucei
ent> <title> <p>Highlights from the Fourth International Society for Computational Biology (ISCB) Student Council Symposium</p> </title> <editor>Lu...
Bridget Chukualim, Nick Peters, Christiane Hertz-F...
BMCBI
2008
110views more  BMCBI 2008»
13 years 11 months ago
Testing for treatment effects on gene ontology
In studies that use DNA arrays to assess changes in gene expression, it is preferable to measure the significance of treatment effects on a group of genes from a pathway or functi...
Taewon Lee, Varsha G. Desai, Cruz Velasco, Robert ...