BMCBI
2008
13 years 11 months ago
2008
Background: The import of most intraperoxisomal proteins is mediated by peroxisome targeting signals at their C-termini (PTS1) or N-terminal regions (PTS2). Both signals have been...
BMCBI
2008
13 years 11 months ago
2008
Background: Historically, two categories of computational algorithms (alignment-based and alignment-free) have been applied to sequence comparison
BMCBI
2008
13 years 11 months ago
2008
BMCBI
2008
13 years 11 months ago
2008
Background: Ionic current blockade signal processing, for use in nanopore detection, offers a promising new way to analyze single molecule properties with potential implications f...
BMCBI
2008
13 years 11 months ago
2008
teps. First, we abstracted protein interactions onto orthologous cluster links. For a given source interaction, if both proteins belonged to a cluster, we constructed a link betwee...
BMCBI
2008
13 years 11 months ago
2008
We explore a linguistically motivated approach to the problem of recognizing speculative language ("hedging") in biomedical research articles. We describe a method, whic...
BMCBI
2008
13 years 11 months ago
2008
Background: The fast growing Protein Data Bank contains the three-dimensional description of more than 45000 protein- and nucleic-acid structures today. The large majority of the ...
BMCBI
2008
13 years 11 months ago
2008
Background: MicroRNAs (miRNAs) are a set of small non-coding RNAs serving as important negative gene regulators. In animals, miRNAs turn down protein translation by binding to the...
BMCBI
2008
13 years 11 months ago
2008
Background: Prediction of protein solvent accessibility, also called accessible surface area (ASA) prediction, is an important step for tertiary structure prediction directly from...
BMCBI
2008
13 years 11 months ago
2008
: The tumour suppressor protein p53 protein has a core domain that binds DNA and is the site for most oncogenic mutations. This domain is quite unstable compared to its homologs p...