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    ISMB
    1998
    193views Computational Biology» more  ISMB 1998»
    Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules
    14 years 26 days ago
    Identification of Divergent Functions in Homologous Proteins by Induction over Conserved Modules
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    Homologousproteins do not necessarily exhibit identical biochemicalfunction. Despitethis fact, local or global sequence similarity is widely used as an indication of functional id...
    Imran Shah, Lawrence Hunter
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    ISMB
    1998
    84views Computational Biology» more  ISMB 1998»
    A Surface Measure for Probabilistic Structural Computations
    14 years 26 days ago
    A Surface Measure for Probabilistic Structural Computations
    Download  www.aaai.org
    Computingthree-dimensional structures from sparse experimentalconstraints requires methodsfor combining heterogeneoussourcesof information,such as distances, angles, andmeasuresof...
    Jeanette P. Schmidt, Cheng Che Chen, Jonathan L. C...
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    ISMB
    1998
    122views Computational Biology» more  ISMB 1998»
    Sequence Assembly Validation by Multiple Restriction Digest Fragment Coverage Analysis
    14 years 26 days ago
    Sequence Assembly Validation by Multiple Restriction Digest Fragment Coverage Analysis
    Download  www.stateslab.org
    DNA sequence analysis depends on the accurate assembly of fragment reads for the determination of a consensus sequence. This report examines the possibility of analyzing multiple,...
    Eric C. Rouchka, David J. States
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    ISMB
    1998
    153views Computational Biology» more  ISMB 1998»
    A Hidden Markov Model for Predicting Transmembrane Helices in Protein Sequences
    14 years 26 days ago
    A Hidden Markov Model for Predicting Transmembrane Helices in Protein Sequences
    Download  digital.cs.usu.edu
    A novel method to model and predict the location and orientation of alpha helices in membrane- spanning proteins is presented. It is based on a hidden Markov model (HMM) with an a...
    Erik L. L. Sonnhammer, Gunnar von Heijne, Anders K...
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    ISMB
    1998
    141views Computational Biology» more  ISMB 1998»
    Bayesian Protein Family Classifier
    14 years 26 days ago
    Bayesian Protein Family Classifier
    Download  www.aaai.org
    A Bayesian procedure for the simultaneous alignment and classification of sequences into subclasses is described. This Gibbs sampling algorithm iterates between an alignment step ...
    Kunbin Qu, Lee Ann McCue, Charles E. Lawrence
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    ISMB
    1998
    101views Computational Biology» more  ISMB 1998»
    Phylogenetic Inference in Protein Superfamilies: Analysis of SH2 Domains
    14 years 26 days ago
    Phylogenetic Inference in Protein Superfamilies: Analysis of SH2 Domains
    Download  www.aaai.org
    This workfocuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify keypositions in the structure, to infer a...
    Kimmen Sjölander
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    ISMB
    1998
    76views Computational Biology» more  ISMB 1998»
    Segment-Based Scores for Pairwise and Multiple Sequence Alignments
    14 years 26 days ago
    Segment-Based Scores for Pairwise and Multiple Sequence Alignments
    Download  www.aaai.org
    Burkhard Morgenstern, William R. Atchley, Klaus Ha...
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    ISMB
    1998
    118views Computational Biology» more  ISMB 1998»
    Prediction of Signal Peptides and Signal Anchors by a Hidden Markov Model
    14 years 26 days ago
    Prediction of Signal Peptides and Signal Anchors by a Hidden Markov Model
    Download  www.cbs.dtu.dk
    A hidden Markov model of signal peptides has been developed. It contains submodels for the N-terminal part, the hydrophobic region, and the region around the cleavage site. For kn...
    Henrik Nielsen, Anders Krogh
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    ISMB
    1998
    88views Computational Biology» more  ISMB 1998»
    Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease
    14 years 26 days ago
    Modeling Protein Homopolymeric Repeats: Possible Polyglutamine Structural Motifs for Huntington's Disease
    Download  www.aaai.org
    Wedescribe a prototype system (Poly-X) for assisting an expert user in modelingprotein repeats. Poly-X reduces the large numberof degrees of freedomrequired to specify a protein m...
    Richard H. Lathrop, Malcolm S. Casale, Douglas J. ...
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    ISMB
    1998
    88views Computational Biology» more  ISMB 1998»
    Hierarchical Minimization with Distance and Angle Constraints
    14 years 26 days ago
    Hierarchical Minimization with Distance and Angle Constraints
    Download  www.aaai.org
    John R. Gunn
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