BMCBI
2006
13 years 11 months ago
2006
Background: In the current era of high throughput genomics a major challenge is the genome-wide identification of target genes for specific transcription factors. Chromatin immuno...
BMCBI
2006
13 years 11 months ago
2006
Background: Accurate methods for extraction of meaningful patterns in high dimensional data have become increasingly important with the recent generation of data types containing ...
BMCBI
2006
13 years 11 months ago
2006
Background: The high-density oligonucleotide microarray (GeneChip) is an important tool for molecular biological research aiming at large-scale detection of small nucleotide polym...
BMCBI
2006
13 years 11 months ago
2006
Background: It has become increasingly apparent that a comprehensive database of RNA motifs is essential in order to achieve new goals in genomic and proteomic research. Secondary...
BMCBI
2006
13 years 11 months ago
2006
Background: Many vital biological processes, including transcription and splicing, require a combination of short, degenerate sequence patterns, or motifs, adjacent to defined seq...
BMCBI
2006
13 years 11 months ago
2006
Background: Gene expression microarray technology permits the analysis of global gene expression profiles. The amount of sample needed limits the use of small excision biopsies an...
BMCBI
2006
2006
ZCURVE_V: a new self-training system for recognizing protein-coding genes in viral and phage genomes
13 years 11 months ago
Background: It necessary to use highly accurate and statistics-based systems for viral and phage genome annotations. The GeneMark systems for gene-finding in virus and phage genom...
BMCBI
2006
13 years 11 months ago
2006
Background: The incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust ex...
BMCBI
2006
13 years 11 months ago
2006
Background: That the structure determines the function of proteins is a central paradigm in biology. However, protein functions are more directly related to cooperative effects at...