BMCBI
2006
13 years 11 months ago
2006
Background: Biochemically detailed stoichiometric matrices have now been reconstructed for various bacteria, yeast, and for the human cardiac mitochondrion based on genomic and pr...
BMCBI
2006
13 years 11 months ago
2006
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
BMCBI
2006
13 years 11 months ago
2006
Background: A new method for the prediction of protein structural classes is constructed based on Rough Sets algorithm, which is a rule-based data mining method. Amino acid compos...
BMCBI
2006
13 years 11 months ago
2006
Background: Proteomics is the study of the proteome, and is critical to the understanding of cellular processes. Two central and related tasks of proteomics are protein identifica...
BMCBI
2006
13 years 11 months ago
2006
Background: Gene expression microarray data is notoriously subject to high signal variability. Moreover, unavoidable variation in the concentration of transcripts applied to micro...
BMCBI
2006
13 years 11 months ago
2006
Background: The goal of information integration in systems biology is to combine information from a number of databases and data sets, which are obtained from both high and low th...
BMCBI
2006
13 years 11 months ago
2006
Background: Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such...
BMCBI
2006
13 years 11 months ago
2006
Background: The development of algorithms to infer the structure of gene regulatory networks based on expression data is an important subject in bioinformatics research. Validatio...
BMCBI
2006
13 years 11 months ago
2006
Background: T cells recognize a complex between a specific major histocompatibility complex (MHC) molecule and a particular pathogen-derived epitope. A given epitope will elicit a...