BMCBI
2007
14 years 18 days ago
2007
Background: Incorrectly annotated sequence data are becoming more commonplace as databases increasingly rely on automated techniques for annotation. Hence, there is an urgent need...
BMCBI
2007
14 years 18 days ago
2007
Background: Fluorescence microscopy is widely used to determine the subcellular location of proteins. Efforts to determine location on a proteome-wide basis create a need for auto...
BMCBI
2007
14 years 18 days ago
2007
Background: RNA interference has revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdo...
BMCBI
2007
14 years 18 days ago
2007
Background: Currently, there exists tens of different microbial and eukaryotic metabolic reconstructions (e.g., Escherichia coli, Saccharomyces cerevisiae, Bacillus subtilis) with...
BMCBI
2007
14 years 18 days ago
2007
Background: DNA melting curve analysis using double-stranded DNA-specific dyes such as SYTO9 produce complex and reproducible melting profiles, resulting in the detection of multi...
BMCBI
2007
14 years 18 days ago
2007
Background: Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive ...
BMCBI
2007
14 years 18 days ago
2007
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
BMCBI
2007
14 years 18 days ago
2007
Background: Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expres...
BMCBI
2007
14 years 18 days ago
2007
Background: Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans...
BMCBI
2007
14 years 18 days ago
2007
Background: Biological sequence repeats arranged in tandem patterns are widespread in DNA and proteins. While many software tools have been designed to detect DNA tandem repeats (...