BMCBI
2007
13 years 7 months ago
2007
Background: Incorrectly annotated sequence data are becoming more commonplace as databases increasingly rely on automated techniques for annotation. Hence, there is an urgent need...
BMCBI
2007
13 years 7 months ago
2007
Background: Fluorescence microscopy is widely used to determine the subcellular location of proteins. Efforts to determine location on a proteome-wide basis create a need for auto...
BMCBI
2007
13 years 7 months ago
2007
Background: RNA interference has revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdo...
BMCBI
2007
13 years 7 months ago
2007
Background: Currently, there exists tens of different microbial and eukaryotic metabolic reconstructions (e.g., Escherichia coli, Saccharomyces cerevisiae, Bacillus subtilis) with...
BMCBI
2007
13 years 7 months ago
2007
Background: DNA melting curve analysis using double-stranded DNA-specific dyes such as SYTO9 produce complex and reproducible melting profiles, resulting in the detection of multi...
BMCBI
2007
13 years 7 months ago
2007
Background: Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive ...
BMCBI
2007
13 years 7 months ago
2007
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
BMCBI
2007
13 years 7 months ago
2007
Background: Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expres...
BMCBI
2007
13 years 7 months ago
2007
Background: Scientific workflows improve the process of scientific experiments by making computations explicit, underscoring data flow, and emphasizing the participation of humans...
BMCBI
2007
13 years 7 months ago
2007
Background: Biological sequence repeats arranged in tandem patterns are widespread in DNA and proteins. While many software tools have been designed to detect DNA tandem repeats (...