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BMCBI
2008
85views more  BMCBI 2008»
13 years 11 months ago
Normalizing biomedical terms by minimizing ambiguity and variability
Background: One of the difficulties in mapping biomedical named entities, e.g. genes, proteins, chemicals and diseases, to their concept identifiers stems from the potential varia...
Yoshimasa Tsuruoka, John McNaught, Sophia Ananiado...
BMCBI
2008
141views more  BMCBI 2008»
13 years 11 months ago
Ontology-guided data preparation for discovering genotype-phenotype relationships
Complexity of post-genomic data and multiplicity of mining strategies are two limits to Knowledge Discovery in Databases (KDD) in life sciences. Because they provide a semantic fr...
Adrien Coulet, Malika Smaïl-Tabbone, Pascale ...
BMCBI
2008
158views more  BMCBI 2008»
13 years 11 months ago
Metrics for GO based protein semantic similarity: a systematic evaluation
Background: Several semantic similarity measures have been applied to gene products annotated with Gene Ontology terms, providing a basis for their functional comparison. However,...
Catia Pesquita, Daniel Faria, Hugo P. Bastos, Ant&...
BMCBI
2008
184views more  BMCBI 2008»
13 years 11 months ago
Integrating protein-protein interactions and text mining for protein function prediction
Background: Functional annotation of proteins remains a challenging task. Currently the scientific literature serves as the main source for yet uncurated functional annotations, b...
Samira Jaeger, Sylvain Gaudan, Ulf Leser, Dietrich...
BMCBI
2008
208views more  BMCBI 2008»
13 years 11 months ago
GraphFind: enhancing graph searching by low support data mining techniques
Background: Biomedical and chemical databases are large and rapidly growing in size. Graphs naturally model such kinds of data. To fully exploit the wealth of information in these...
Alfredo Ferro, Rosalba Giugno, Misael Mongiov&igra...
BMCBI
2008
93views more  BMCBI 2008»
13 years 11 months ago
Ranking single nucleotide polymorphisms by potential deleterious effects
Identifying single nucleotide polymorphisms (SNPs) that are responsible for common and complex diseases such as cancer is of major interest in current molecular epidemiology. Howe...
Phil Hyoun Lee, Hagit Shatkay
BMCBI
2008
119views more  BMCBI 2008»
13 years 11 months ago
On deducing causality in metabolic networks
Background: Metabolic networks present a complex interconnected structure, whose understanding is in general a non-trivial task. Several formal approaches have been developed to s...
Chiara Bodei, Andrea Bracciali, Davide Chiarugi
BMCBI
2008
66views more  BMCBI 2008»
13 years 11 months ago
Modelling the structures of G protein-coupled receptors aided by three-dimensional validation
Siavoush Dastmalchi, W. Bret Church, Michael B. Mo...