BMCBI
2008
13 years 11 months ago
2008
Background: Understanding how genes are expressed and regulated in different tissues is a fundamental and challenging question. However, most of currently available biological dat...
BMCBI
2008
13 years 11 months ago
2008
Background: In cancer research, most clinical variables have already been investigated and are now well established. The use of transcriptomic variables has raised two problems: r...
BMCBI
2008
13 years 11 months ago
2008
Background: Population structure analysis is important to genetic association studies and evolutionary investigations. Parametric approaches, e.g. STRUCTURE and L-POP, usually ass...
BMCBI
2008
13 years 11 months ago
2008
Background: Recent genomic scale survey of epigenetic states in the mammalian genomes has shown that promoters and enhancers are correlated with distinct chromatin signatures, pro...
BMCBI
2008
13 years 11 months ago
2008
Background: Sequences and structures provide valuable complementary information on protein features and functions. However, it is not always straightforward for users to gather in...
BMCBI
2008
13 years 11 months ago
2008
Background: R is the preferred tool for statistical analysis of many bioinformaticians due in part to the increasing number of freely available analytical methods. Such methods ca...
BMCBI
2008
13 years 11 months ago
2008
Background: We propose a multiple sequence alignment (MSA) algorithm and compare the alignment-quality and execution-time of the proposed algorithm with that of existing algorithm...
BMCBI
2008
13 years 11 months ago
2008
BMCBI
2008
13 years 11 months ago
2008
Background: The increasing availability of fungal genome sequences provides large numbers of proteins for evolutionary and phylogenetic analyses. However the heterogeneity of data...
BMCBI
2008
13 years 11 months ago
2008
Background: DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a va...