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    BMCBI
    2008
    95views more  BMCBI 2008»
    Methodology capture: discriminating between the "best" and the rest of community practice
    13 years 11 months ago
    Methodology capture: discriminating between the "best" and the rest of community practice
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    Background: The methodologies we use both enable and help define our research. However, as experimental complexity has increased the choice of appropriate methodologies has become...
    James M. Eales, John W. Pinney, Robert D. Stevens,...
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    BMCBI
    2008
    90views more  BMCBI 2008»
    Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
    13 years 11 months ago
    Genome-scale study of the importance of binding site context for transcription factor binding and gene regulation
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    Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
    Jakub Orzechowski Westholm, Feifei Xu, Hans Ronne,...
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    BMCBI
    2008
    75views more  BMCBI 2008»
    Highlighting computations in bioscience and bioinformatics: review of the Symposium of Computations in Bioinformatics and Biosci
    13 years 11 months ago
    Highlighting computations in bioscience and bioinformatics: review of the Symposium of Computations in Bioinformatics and Biosci
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    Guoqing Lu, Jun Ni
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    BMCBI
    2008
    142views more  BMCBI 2008»
    Genetic weighted k-means algorithm for clustering large-scale gene expression data
    13 years 11 months ago
    Genetic weighted k-means algorithm for clustering large-scale gene expression data
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    Background: The traditional (unweighted) k-means is one of the most popular clustering methods for analyzing gene expression data. However, it suffers three major shortcomings. It...
    Fang-Xiang Wu
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    BMCBI
    2008
    219views more  BMCBI 2008»
    Classification of premalignant pancreatic cancer mass-spectrometry data using decision tree ensembles
    13 years 11 months ago
    Classification of premalignant pancreatic cancer mass-spectrometry data using decision tree ensembles
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    Background: Pancreatic cancer is the fourth leading cause of cancer death in the United States. Consequently, identification of clinically relevant biomarkers for the early detect...
    Guangtao Ge, G. William Wong
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    BMCBI
    2008
    87views more  BMCBI 2008»
    Protein structure search and local structure characterization
    13 years 11 months ago
    Protein structure search and local structure characterization
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    Background: Structural similarities among proteins can provide valuable insight into their functional mechanisms and relationships. As the number of available three-dimensional (3...
    Shih-Yen Ku, Yuh-Jyh Hu
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    BMCBI
    2008
    65views more  BMCBI 2008»
    Supervised inference of gene-regulatory networks
    13 years 11 months ago
    Supervised inference of gene-regulatory networks
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    Cuong To, Jiri Vohradsky
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    BMCBI
    2008
    91views more  BMCBI 2008»
    PageRank without hyperlinks: Reranking with PubMed related article networks for biomedical text retrieval
    13 years 11 months ago
    PageRank without hyperlinks: Reranking with PubMed related article networks for biomedical text retrieval
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    Background: Graph analysis algorithms such as PageRank and HITS have been successful in Web environments because they are able to extract important inter-document relationships fr...
    Jimmy J. Lin
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    BMCBI
    2008
    138views more  BMCBI 2008»
    Systematic identification of yeast cell cycle transcription factors using multiple data sources
    13 years 11 months ago
    Systematic identification of yeast cell cycle transcription factors using multiple data sources
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    Background: Eukaryotic cell cycle is a complex process and is precisely regulated at many levels. Many genes specific to the cell cycle are regulated transcriptionally and are exp...
    Wei-Sheng Wu, Wen-Hsiung Li
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    BMCBI
    2008
    122views more  BMCBI 2008»
    Generating samples for association studies based on HapMap data
    13 years 11 months ago
    Generating samples for association studies based on HapMap data
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    Background: With the completion of the HapMap project, a variety of computational algorithms and tools have been proposed for haplotype inference, tag SNP selection and genome-wid...
    Jing Li, Yixuan Chen
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