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BMCBI
2007
247views more  BMCBI 2007»
13 years 11 months ago
A survey of DNA motif finding algorithms
Background: Unraveling the mechanisms that regulate gene expression is a major challenge in biology. An important task in this challenge is to identify regulatory elements, especi...
Modan K. Das, Ho-Kwok Dai
BMCBI
2007
180views more  BMCBI 2007»
13 years 11 months ago
Splicy: a web-based tool for the prediction of possible alternative splicing events from Affymetrix probeset data
Background: The Affymetrix™ technology is nowadays a well-established method for the analysis of gene expression profiles in cancer research studies. However, changes in gene ex...
Davide Rambaldi, Barbara Felice, Viviane Praz, Phi...
BMCBI
2007
136views more  BMCBI 2007»
13 years 11 months ago
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees
Background: In vertebrates, a large part of gene transcriptional regulation is operated by cisregulatory modules. These modules are believed to be regulating much of the tissue-sp...
Xiaoyu Chen, Mathieu Blanchette
BMCBI
2007
167views more  BMCBI 2007»
13 years 11 months ago
A stochastic differential equation model for transcriptional regulatory networks
Background: This work explores the quantitative characteristics of the local transcriptional regulatory network based on the availability of time dependent gene expression data se...
Adriana Climescu-Haulica, Michelle D. Quirk
IJDMB
2008
117views more  IJDMB 2008»
13 years 11 months ago
Scoring and summarising gene product clusters using the Gene Ontology
: We propose an approach for quantifying the biological relatedness between gene products, based on their properties, and measure their similarities using exclusively statistical N...
Spiridon C. Denaxas, Christos Tjortjis
BMCBI
2007
103views more  BMCBI 2007»
13 years 11 months ago
Systems biology approach for mapping the response of human urothelial cells to infection by Enterococcus faecalis
Background: To better understand the response of urinary epithelial (urothelial) cells to Enterococcus faecalis, a uropathogen that exhibits resistance to multiple antibiotics, a ...
Mikhail G. Dozmorov, Kimberly D. Kyker, Ricardo Sa...
BMCBI
2007
101views more  BMCBI 2007»
13 years 11 months ago
Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
Background: Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plant...
Nan Mei, Lei Guo, Ruqing Liu, James C. Fuscoe, Tao...
BMCBI
2007
109views more  BMCBI 2007»
13 years 11 months ago
Discarding duplicate ditags in LongSAGE analysis may introduce significant error
Background: During gene expression analysis by Serial Analysis of Gene Expression (SAGE), duplicate ditags are routinely removed from the data analysis, because they are suspected...
Jeppe Emmersen, Anna M. Heidenblut, Annabeth Laurs...
BMCBI
2007
154views more  BMCBI 2007»
13 years 11 months ago
h-Profile plots for the discovery and exploration of patterns in gene expression data with an application to time course data
Background: An ever increasing number of techniques are being used to find genes with similar profiles from microarray studies. Visualization of gene expression profiles can aid t...
Yvonne E. Pittelkow, Susan R. Wilson
BMCBI
2007
111views more  BMCBI 2007»
13 years 11 months ago
MotifCombinator: a web-based tool to search for combinations of cis-regulatory motifs
Background: A combination of multiple types of transcription factors and cis-regulatory elements is often required for gene expression in eukaryotes, and the combinatorial regulat...
Mamoru Kato, Tatsuhiko Tsunoda