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» Logic-Based Modeling in Systems Biology
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ISCAS
2006
IEEE
162views Hardware» more  ISCAS 2006»
15 years 10 months ago
Silicon neurons that phase-lock
Abstract—We present a silicon neuron with a dynamic, active leak that enables precise spike-timing with respect to a time-varying input signal. Our neuron models the mammalian bu...
J. H. Wittig Jr., Kwabena Boahen
BMCBI
2006
175views more  BMCBI 2006»
15 years 4 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...
RECOMB
2006
Springer
16 years 4 months ago
Genome-Wide Discovery of Modulators of Transcriptional Interactions in Human B Lymphocytes
Abstract. Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription fa...
Kai Wang, Ilya Nemenman, Nilanjana Banerjee, Adam ...
NAR
2011
374views Computer Vision» more  NAR 2011»
14 years 10 months ago
The BioGRID Interaction Database: 2011 update
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms ...
Chris Stark, Bobby-Joe Breitkreutz, Andrew Chatr-a...
BMCBI
2007
146views more  BMCBI 2007»
15 years 4 months ago
Spatial location and its relevance for terminological inferences in bio-ontologies
Background: An adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggr...
Stefan Schulz, Kornél G. Markó, Udo ...