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BMCBI
2006
82views more  BMCBI 2006»
13 years 11 months ago
A method for computing the overall statistical significance of a treatment effect among a group of genes
Background: In studies that use DNA arrays to assess changes in gene expression, our goal is to evaluate the statistical significance of treatments on sets of genes. Genes can be ...
Robert R. Delongchamp, Taewon Lee, Cruz Velasco
BMCBI
2006
136views more  BMCBI 2006»
13 years 11 months ago
Metric for Measuring the Effectiveness of Clustering of DNA Microarray Expression
Background: The recent advancement of microarray technology with lower noise and better affordability makes it possible to determine expression of several thousand genes simultane...
Raja Loganantharaj, Satish Cheepala, John Clifford
BMCBI
2006
149views more  BMCBI 2006»
13 years 11 months ago
Curation of viral genomes: challenges, applications and the way forward
Background: Whole genome sequence data is a step towards generating the 'parts list' of life to understand the underlying principles of Biocomplexity. Genome sequencing ...
Urmila Kulkarni-Kale, Shriram Bhosle, G. Sunitha M...
BMCBI
2006
123views more  BMCBI 2006»
13 years 11 months ago
An Automated Method for Rapid Identification of Putative Gene Family Members in Plants
Background: Gene duplication events have played a significant role in genome evolution, particularly in plants. Exhaustive searches for all members of a known gene family as well ...
Ronald L. Frank, Ajay Mane, Fikret Erçal
BMCBI
2006
111views more  BMCBI 2006»
13 years 11 months ago
PepDist: A New Framework for Protein-Peptide Binding Prediction based on Learning Peptide Distance Functions
Background: Many different aspects of cellular signalling, trafficking and targeting mechanisms are mediated by interactions between proteins and peptides. Representative examples...
Tomer Hertz, Chen Yanover
BMCBI
2006
141views more  BMCBI 2006»
13 years 11 months ago
Maximum common subgraph: some upper bound and lower bound results
Background: Structure matching plays an important part in understanding the functional role of biological structures. Bioinformatics assists in this effort by reformulating this p...
Xiuzhen Huang, Jing Lai, Steven F. Jennings
BMCBI
2006
102views more  BMCBI 2006»
13 years 11 months ago
MycoperonDB: a database of computationally identified operons and transcriptional units in Mycobacteria
Background: A key post genomics challenge is to identify how genes in an organism come together and perform physiological functions. An important first step in this direction is t...
Sarita Ranjan, Ranjit Kumar Gundu, Akash Ranjan
BMCBI
2006
65views more  BMCBI 2006»
13 years 11 months ago
Particle simulation approach for subcellular dynamics and interactions of biological molecules
Ryuzo Azuma, Tetsuji Kitagawa, Hiroshi Kobayashi, ...
BMCBI
2006
121views more  BMCBI 2006»
13 years 11 months ago
Splice site identification using probabilistic parameters and SVM classification
Background: Recent advances and automation in DNA sequencing technology has created a vast amount of DNA sequence data. This increasing growth of sequence data demands better and ...
A. K. M. A. Baten, Bill C. H. Chang, Saman K. Halg...
BMCBI
2006
139views more  BMCBI 2006»
13 years 11 months ago
DNA Molecule Classification Using Feature Primitives
Background: We present a novel strategy for classification of DNA molecules using measurements from an alpha-Hemolysin channel detector. The proposed approach provides excellent c...
Raja Tanveer Iqbal, Matthew Landry, Stephen Winter...