BMCBI
2006
13 years 11 months ago
2006
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
BMCBI
2006
13 years 11 months ago
2006
Background: In our previous studies, we found that the sites in prokaryotic genomes which are most susceptible to duplex destabilization under the negative superhelical stresses t...
BMCBI
2006
13 years 11 months ago
2006
Background: Horizontal gene transfer (HGT) is considered a strong evolutionary force shaping the content of microbial genomes in a substantial manner. It is the difference in spee...
BMCBI
2006
13 years 11 months ago
2006
Background: Protein topology representations such as residue contact maps are an important intermediate step towards ab initio prediction of protein structure. Although improvemen...
BMCBI
2006
13 years 11 months ago
2006
Background: Single nucleotide polymorphisms (SNPs) are locations at which the genomic sequences of population members differ. Since these differences are known to follow patterns,...
BMCBI
2006
13 years 11 months ago
2006
Background: The identification of biologically interesting genes in a temporal expression profiling dataset is challenging and complicated by high levels of experimental noise. Mo...
BMCBI
2006
13 years 11 months ago
2006
Background: Vast progress in sequencing projects has called for annotation on a large scale. A Number of methods have been developed to address this challenging task. These method...
BMCBI
2006
13 years 11 months ago
2006
Background: Understanding the relationship between gene expression changes, enzyme activity shifts, and the corresponding physiological adaptive response of organisms to environme...
BMCBI
2006
13 years 11 months ago
2006
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
BMCBI
2006
13 years 11 months ago
2006
