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BMCBI
2006
90views more  BMCBI 2006»
13 years 11 months ago
Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data
Background: Trait heterogeneity, which exists when a trait has been defined with insufficient specificity such that it is actually two or more distinct traits, has been implicated...
Tricia A. Thornton-Wells, Jason H. Moore, Jonathan...
BMCBI
2006
99views more  BMCBI 2006»
13 years 11 months ago
Genetic algorithm learning as a robust approach to RNA editing site prediction
Background: RNA editing is one of several post-transcriptional modifications that may contribute to organismal complexity in the face of limited gene complement in a genome. One f...
James Thompson, Shuba Gopal
BMCBI
2006
108views more  BMCBI 2006»
13 years 11 months ago
A new pooling strategy for high-throughput screening: the Shifted Transversal Design
Background: In binary high-throughput screening projects where the goal is the identification of low-frequency events, beyond the obvious issue of efficiency, false positives and ...
Nicolas Thierry-Mieg
BMCBI
2006
120views more  BMCBI 2006»
13 years 11 months ago
SCOWLP: a web-based database for detailed characterization and visualization of protein interfaces
Background: Currently there is a strong need for methods that help to obtain an accurate description of protein interfaces in order to be able to understand the principles that go...
Joan Teyra, Andreas Doms, Michael Schroeder, M. Te...
BMCBI
2006
108views more  BMCBI 2006»
13 years 11 months ago
RibAlign: a software tool and database for eubacterial phylogeny based on concatenated ribosomal protein subunits
Background: Until today, analysis of 16S ribosomal RNA (rRNA) sequences has been the de-facto gold standard for the assessment of phylogenetic relationships among prokaryotes. How...
Hanno Teeling, Frank Oliver Glöckner
BMCBI
2006
74views more  BMCBI 2006»
13 years 11 months ago
An unsupervised classification scheme for improving predictions of prokaryotic TIS
Background: Although it is not difficult for state-of-the-art gene finders to identify coding regions in prokaryotic genomes, exact prediction of the corresponding translation ini...
Maike Tech, Peter Meinicke
BMCBI
2006
118views more  BMCBI 2006»
13 years 11 months ago
Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration
Background: There is an ever increasing rate of data made available on genetic variation, transcriptomes and proteomes. Similarly, a growing variety of bioinformatic programs are ...
Erdahl T. Teber, Edward Crawford, Kent B. Bolton, ...
BMCBI
2006
201views more  BMCBI 2006»
13 years 11 months ago
Gene selection algorithms for microarray data based on least squares support vector machine
Background: In discriminant analysis of microarray data, usually a small number of samples are expressed by a large number of genes. It is not only difficult but also unnecessary ...
E. Ke Tang, Ponnuthurai N. Suganthan, Xin Yao