Background: Genomic deletions and duplications are important in the pathogenesis of diseases, such as cancer and mental retardation, and have recently been shown to occur frequent...
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
Background: Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures t...
Background: Helical membrane proteins (HMPs) play a crucial role in diverse cellular processes, yet it still remains extremely difficult to determine their structures by experimen...
Background: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. For many initiatives, such as the Protein Structure Initi...
Russell L. Marsden, Tony A. Lewis, Christine A. Or...
Background: The translation start site plays an important role in the control of translation efficiency of eukaryotic mRNAs. The recognition of the start AUG codon by eukaryotic r...
Alexey V. Kochetov, Andrey Palyanov, Igor I. Titov...
Background: Modeling of metabolic networks includes tasks such as network assembly, network overview, calculation of metabolic fluxes and testing the robustness of the network. Re...
Roland Schwarz, Chunguang Liang, Christoph Kaleta,...
Background: Computational analysis of gene regulatory regions is important for prediction of functions of many uncharacterized genes. With this in mind, search of the target genes...
Elena A. Ananko, Yury V. Kondrakhin, Tatyana I. Me...