BMCBI
2007
14 years 19 days ago
2007
Background: Detecting groups of functionally related proteins from their amino acid sequence alone has been a long-standing challenge in computational genome research. Several clu...
BMCBI
2007
14 years 19 days ago
2007
Background: Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms...
BMCBI
2007
14 years 19 days ago
2007
Background: Cell specific gene expression is largely regulated by different combinations of transcription factors that bind cis-elements in the upstream promoter sequence. However...
BMCBI
2007
2007
Penalized likelihood for sparse contingency tables with an application to full-length cDNA libraries
14 years 19 days ago
Background: The joint analysis of several categorical variables is a common task in many areas of biology, and is becoming central to systems biology investigations whose goal is ...
BMCBI
2007
14 years 19 days ago
2007
Background: The combination of mass spectrometry and solution phase amide hydrogen/deuterium exchange (H/D exchange) experiments is an effective method for characterizing protein ...
BMCBI
2007
14 years 19 days ago
2007
Background: Predicting protein complexes from experimental data remains a challenge due to limited resolution and stochastic errors of high-throughput methods. Current algorithms ...
BMCBI
2007
14 years 19 days ago
2007
Background: With the advent of increasing sequence and structural data, a number of methods have been proposed to locate putative protein binding sites from protein surfaces. Ther...
BMCBI
2007
14 years 19 days ago
2007
Background: Structure identification of dynamic models for complex biological systems is the cornerstone of their reverse engineering. Biochemical Systems Theory (BST) offers a pa...
BMCBI
2007
14 years 19 days ago
2007
Background: Deficiencies in microarray technology cause unwanted variation in the hybridization signal, obscuring the true measurements of intracellular transcript levels. Here we...
BMCBI
2007
14 years 19 days ago
2007
Background: Whole genome shotgun sequencing produces increasingly higher coverage of a genome with random sequence reads. Progressive whole genome assembly and eventual finishing ...