BMCBI
2006
13 years 11 months ago
2006
Background: Gene regulation and metabolic reactions are two primary activities of life. Although many works have been dedicated to study each system, the coupling between them is ...
BMCBI
2006
13 years 11 months ago
2006
Background: As biology becomes an increasingly computational science, it is critical that we develop software tools that support not only bioinformaticians, but also bench biologi...
BMCBI
2006
13 years 11 months ago
2006
Background: DNA microarrays are popular tools for measuring gene expression of biological samples. This ever increasing popularity is ensuring that a large number of microarray st...
BMCBI
2006
13 years 11 months ago
2006
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are...
BMCBI
2006
13 years 11 months ago
2006
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
BMCBI
2006
13 years 11 months ago
2006
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
BMCBI
2006
13 years 11 months ago
2006
BMCBI
2006
13 years 11 months ago
2006
Sequence homologs are an important source of information about proteins. Amino acid profiles, representing the position-specific mutation probabilities found in profiles, are a ri...
BMCBI
2006
13 years 11 months ago
2006
Background: Grid computing has great potential to become a standard cyberinfrastructure for life sciences which often require high-performance computing and large data handling wh...
BMCBI
2006
13 years 11 months ago
2006
Background: Knowledge of protein domain boundaries is critical for the characterisation and understanding of protein function. The ability to identify domains without the knowledg...